To make a portable install in OSX: make a folder (say "REAPER_portable"), create an empty file reaper.ini in this folder, drag-drop REAPER.app or REAPER64.app from the disk image (.dmg) into this folder. If you need the SWS extension for this portable install too: drag-drop the reaper_sws.dylib from the SWS' disk image to "REAPER_portable/UserPlugins" (do not use the install script for portable installs!).